The International Space Station is available to businesses of all shapes and sizes. Increasingly, startup companies have been drawn to the unique opportunity to conduct research and development in space. MassChallenge is the largest-ever startup accelerator and the first to support high-impact, early-stage entrepreneurs. Its four-month accelerator program offers world-class mentorship, in-kind support,and other benefits to help startup businesses succeed. A unique collaboration formed in 2014 between MassChallenge, Boeing,and the ISS National Laboratory that has led to numerous research experiments on the space station.