You are more like a mouse than you think! Rodents are the most common model organism used in experimental studies of human disease, and extensive rodent research has been conducted onboard the ISS. Space-based rodent research has used multiple strains of mice to investigate a wide array of research questions. Areas of interest include muscle wasting, bone density degradation, neuroscience, and wound healing. This panel discussion focused on the ways in which a diverse cadre of researchers are leveraging the mouse model in microgravity to improve health both on Earth and in space.