In 2013, the ISS National Lab began their partnership with MassChallenge to better educate those within startup communities on the research possibilities that existed on the ISS. Since then, The ISS National Lab has partnered with Boeing to award grants through a MassChallenge Boston “Technology in Space” prize. Grants to awarded companies provide seed funding and assist with hardware costs for flight to the space station. This discussion will focus on previous grantees and how the program served as springboard for business success.