Day 1 was held on August 3, 2021, with session topics including:
- Welcome and opening with NASA Administrator Sen. Bill Nelson; John Mulholland, Boeing Vice President and ISS Program Manager; and Joel Montalbano, ISS Program Office Manager, NASA
- Keynote: In Conversation With Dr. Francis Collins and Dr. Kate Rubins
- Panel Session: The Next Decade of ISS Research
- Panel Session: In-Space Production Applications in the Low Earth Orbit Economy
- Fireside Chat With Dr. William Wagner: Biomanufacturing in Space: A Paradigm Shift in Regenerative Medicine