Humans have been living on the ISS for over two decades and today commercial astronauts have joined their NASA counterparts. As the number people traveling to, and spending time in, space increases, our understanding of the physiological responses of humans must increase as well. Join us for this panel of experts as they discuss how we leverage the ISS to improve human performance in commercial space habitats, what new human interfaces might exist in a commercial environment (i.e. robotics, AI), and how do we shape processes for balancing risk between NASA requirements and commercial interests.